According to Mike Russell, MD: "If you weigh 180 pounds and your goal weight is 130 pounds, losing 20 pounds in one week—the right way—teeters on the brink of impossible. If you’re more like a Biggest Loser contestant, weighing 380 pounds, then losing 20 pounds in one week is plausible (especially considering a large amount of water weight you would lose during the first week)."

On presentation, the patient appeared in mild distress secondary to his stated abdominal pain. BMI on admission was 27.1 (weight 91 kilograms), vital signs were within normal limits, and the patient appeared euvolemic. Complete physical examination was normal including a normal abdominal examination. Initial laboratory studies revealed a high anion gap metabolic acidosis (arterial ph 7.34, arterial PCO2 23 mmHg, serum bicarbonate 12 mmol/L, serum anion gap 21) and hyperglycemia (serum glucose 267 mg/dL). The patient was found to have both ketonemia and ketonuria. Additional data, including a complete blood count, serum sodium, serum chloride, serum potassium, liver chemistries, lipid fractionation, serum lipase, serum amylase, plain chest radiography, and computed tomography of the abdomen and pelvis, were within normal limits. Serum osmolality, urine toxicology and lactic acid levels were not performed.
Generally speaking, it also depends on your size. If you are overly obese, by simply cutting down on junk food and moving your body a bit, you may drop 10 pounds in less than a week easily without causing a health problem. However, for someone who is only slightly overweight or within the normal range wanting to slim down a bit, this is not healthy or sustainable. You may lose weight; but the pounds will creep up again when you stop the diet.
Joel and Sheila Hammond are everyday suburban real estate agents in Santa Clarita, California.[8] The couple face a series of obstacles when Sheila has a physical transformation into a zombie and starts craving human flesh. With Joel and the family trying to help Sheila through the trying time, they have to deal with neighbors, cultural norms and getting to the bottom of a potentially mythological mystery.[9]
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